原创力文档the pharmacokinetics of cefazolin in patients undergoing elective semi-elective abdominal aortic aneurysm open repair surgery头孢唑啉在患者的药物动力学择期 semi-elective腹主动脉瘤修复手术.pdfVIP
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thepharmacokineticsofcefazolininpatientsundergoingelective
Douglas et al. BMC Anesthesiology 2011, 11:5
/1471-2253/11/5
STUDY PROTOCOL Open Access
The pharmacokinetics of cefazolin in patients
undergoing elective semi-elective abdominal
aortic aneurysm open repair surgery
1,2 1,2 1,2 3,4 5
Alexandra Douglas , Mahdi Altukroni , Andrew A Udy , Michael S Roberts , Kersi Taraporewalla ,
Jason Jenkins6, Jeffrey Lipman1,2, Jason A Roberts1,2,7*
Abstract
Background: Surgical site infections are common, so effective antibiotic concentrations at the sites of infection are
required. Surgery can lead to physiological changes influencing the pharmacokinetics of antibiotics. The aim of the
study is to evaluate contemporary peri-operative prophylactic dosing of cefazolin by determining plasma and
subcutaneous interstitial fluid concentrations in patients undergoing elective of semi-elective abdominal aortic
aneurysm (AAA) open repair surgery.
Methods/Design: This is an observational pharmacokinetic study of patients undergoing AAA open repair surgery
at the Royal Brisbane and Women’s Hospital. All patients will be administered 2-g cefazolin by intravenous injection
within 30-minutes of the procedure. Participants will have samples from blood and urine, collected at different
intervals. Patients will also have a microdialysis catheter inserted into subcutaneous tissue to measure interstitial
fluid penetration by cefazolin. Participants will be administered indocyanine green and sodium bromide as well as
have cardiac output monitoring performed and tetrapolar bioimpedance to determine physiological changes
occurring during surgery. Analysis of samples will be performed using validated liquid chromatography tandem
mass-spectrometry. Pharmacokinetic analys
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