原创力文档- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
the pharmacokinetics of the interstitial space in humans人类的药物动力学的间隙空间
BMC Clinical Pharmacology BioMed Central
Research article Open Access
The pharmacokinetics of the interstitial space in humans
David G Levitt*
Address: Department of Physiology University of Minnesota
Email: David G Levitt* - levit001@
* Corresponding author
Published: 30 July 2003 Received: 17 April 2003
Accepted: 30 July 2003
BMC Clinical Pharmacology 2003, 3:3
This article is available from: /1472-6904/3/3
© 2003 Levitt; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for
any purpose, provided this notice is preserved along with the articles original URL.
Abstract
Background: The pharmacokinetics of extracellular solutes is determined by the blood-tissue
exchange kinetics and the volume of distribution in the interstitial space in the different organs. This
information can be used to develop a general physiologically based pharmacokinetic (PBPK) model
applicable to most extracellular solutes.
Methods: The human pharmacokinetic literature was surveyed to tabulate the steady state and
equilibrium volume of distribution of the solutes mannitol, EDTA, morphine-6-glucuronide,
morphine-3-glucuronide, inulin and β-lactam antibiotics with a range of protein binding (amoxicillin,
piperacillin, cefatrizine, ceforanide, flucloxacillin, dicloxacillin). A PBPK data set was developed for
extracellular solutes based on the liter
您可能关注的文档
- an unbiased scientific record should be everyone's agenda一个公正的科学记录应每个人的议程.pdf
- [5-(1,3-diphenyl-1h-pyrazol-4-yl)-3-phenyl-4,5-dihydropyrazol-1-yl](pyridin-4-yl)methanone英文论文.pdf
- a standard addition method to assay the concentration of biologically interesting polyphenols in grape berries by reversed-phase hplc一个标准添加法测定的浓度生物有趣的多酚类物质在葡萄浆果反相高效液相色谱法.pdf
- antioxidant, total phenolic content and cytotoxicity evaluation of selected malaysian plants抗氧化剂,总酚含量和细胞毒性的评价选择马来西亚植物.pdf
- 3-amino-8-hydroxy-4-imino-6-methyl-5-phenyl-4,5-dihydro-3h-chromeno [2,3-d ]pyrimidine an effecient key precursor for novel synthesis of some interesting triazines and triazepines as potential anti-tumor agents英文论文.pdf
- amélioration de la productivité des brebis berrichonnes du cher par croisement. iii. – performances de reproduction des trois premières genérations de brebis croisées entre les races berrichonne du cher et romanov英文论文.pdf
- carnivory in the teasel dipsacus fullonum — the effect of experimental feeding on growth and seed set在川续断carnivory dipsacus fullonumu2014u2014实验喂养对增长的影响和种子.pdf
- common variants in crp and lepr influence high sensitivity c-reactive protein levels in north indians常见的变体c反应蛋白和lepr影响灵敏度高c反应蛋白水平在北印度人.pdf
- arntl (bmal1) and npas2 gene variants contribute to fertility and seasonalityarntl(bmal1)和npas2基因变异导致生育和季节性.pdf
- cost-effectiveness of blood agar for isolation of mycobacteria成本效益的血琼脂分枝杆菌的隔离.pdf
- the peritraumatic behavior questionnaire development and initial validation of a new measure for combat-related peritraumatic reactionsperitraumatic行为问卷开发和初步验证的新措施战争peritraumatic反应.pdf
- the pharmacological effects of morroniside and loganin isolated from liuweidihuang wan, on mc3t3-e1 cellsmorroniside的药理作用和马钱子苷liuweidihuang wan隔绝,在mc3t3-e1细胞.pdf
- the pharmacological chaperone at2220 increases recombinant human acid α-glucosidase uptake and glycogen reduction in a mouse model of pompe disease药理伴侣at2220增加重组人类α-glucosidase吸收酸和糖原减少筛疾病的小鼠模型.pdf
- the ph response and sensing mechanism of n-type znoelectrolyte interfacesph值响应和n型传感机制znoelectrolyte接口.pdf
- the 'permeome' of the malaria parasite an overview of the membrane transport proteins of plasmodium falciparum的permeome疟原虫恶性疟原虫的膜运输蛋白的概述.pdf
- the phd finger of human uhrf1 reveals a new subgroup of unmethylated histone h3 tail readers人类uhrf1博士手指的揭示了一个新子群unmethylated组蛋白h3尾巴读者.pdf
- the phenotype-fitness map in experimental evolution of phagesphenotype-fitness映射在实验噬菌体的进化.pdf
- the pholcodine case. cough medicines, ige-sensitization, and anaphylaxis a devious connection福尔可定的情况。.pdf
- the pharmacokinetics and pharmacodynamics of iron preparations铁制剂的药代学和药效学.pdf
- the phosphatomes of the multicellular myxobacteria myxococcus xanthus and sorangium cellulosum in comparison with other prokaryotic genomes多细胞粘细菌的phosphatomes myxococcus克桑托斯和sorangium cellulosum相比与其他原核生物的基因组.pdf
文档评论（0）