原创力文档the pholcodine case. cough medicines, ige-sensitization, and anaphylaxis a devious connection福尔可定的情况。.pdfVIP
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the pholcodine case. cough medicines, ige-sensitization, and anaphylaxis a devious connection福尔可定的情况。
REVIEW ARTICLE
The Pholcodine Case. Cough Medicines, IgE-Sensitization,
and Anaphylaxis: A Devious Connection
E. Florvaag,1,2 and S. G. O. Johansson3,4
for doctors and researchers within anesthesiology and aller-
Abstract: The Scandinavian data on pholcodine (PHO) strongly
gology but not less for regulatory authorities and national
indicates that there is a biological chain from PHO exposure through
marketing authorization holders. Some are concerned, and
IgE-sensitization to IgE-mediated anaphylaxis to neuromuscular
others obviously less disturbed by the warning signals thus
blocking agents (NMBA). PHO is probably one of the strongest
conveyed. The latter position is often promoted by individuals
inducer of an IgE antibody response known. Of individuals taking
and official bodies obviously not fully taking into account the
PHO in cough medicines, over-the-counter accessibility to large
mechanisms by which PHO seems to work. However, the
populations, as many as 20 to 25% may become IgE sensitized. Once
consequences are to be born by large populations of individ-
sensitized, PHO re-exposure will booster IgE an
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