the phrenic component of acute schizophrenia – a name and its physiological reality急性精神分裂症的膈组件u2014u2014一个名称和其生理现实.pdfVIP

The Phrenic Component of Acute Schizophrenia – A Name and Its Physiological Reality ¨ ¨ 1 1 2 1 1 Karl-Jurgen Bar *, Tobias Rachow , Steffen Schulz , Katharina Bassarab , Stefanie Haufe , 1 3 2 Sandy Berger , Kathrin Koch , Andreas Voss 1 Pain and Autonomic Integrative Research (PAIR), Department of Psychiatry and Psychotherapy, University Hospital, Jena, Germany, 2 Department of Medical Engineering and Biotechnology, University of Applied Sciences, Jena, Germany, 3 Department of Psychiatry and Psychotherapy, University Hospital, Jena, Germany Abstract Decreased heart rate variability (HRV) was shown for unmedicated patients with schizophrenia and their first-degree relatives, implying genetic associations. This is known to be an important risk factor for increased cardiac mortality in other diseases. The interaction of cardio-respiratory function and respiratory physiology has never been investigated in the disease although it might be closely related to the pattern of autonomic dysfunction. We hypothesized that increased breathing rates and reduced cardio-respiratory coupling in patients with acute schizophrenia would be associated with low vagal function. We assessed variability of breathing rates and depth, HRV and cardio-respiratory coupling in patients, their first-degree relatives and controls at rest. Control subjects were investigated a second time by means of a stress task to identify stress-related changes of cardio-respiratory function. A total of 73 subjects were investigated, consisting of 23 unmedicated patients, 20 healthy, first-degree relatives and 30 control subjects matched for age, gender, smo