the p-i concept pharmacological interaction of drugs with immune receptors导出了概念药理作用的药物和免疫受体.pdfVIP

REVIEW ARTICLE The p-i Concept: Pharmacological Interaction of Drugs With Immune Receptors Werner J. Pichler n drug hypersensitivity, 2 extremely polymorphic systems Abstract: The immune response in drug hypersensitivity is normally Iencounter each other. On one hand, modern chemistry, which explained by the hapten hypothesis. It postulates that drugs with a allows synthesis of an endless amount of drugs often designed molecular weight of less than 1000 D are too small to cause an immune to fit into and thus blocking receptors or enzymes and, on the response per se. However, if a chemically reactive drug or drug other hand, the specific immune system, which is composed of metabolite binds covalently to a protein and thus forms a so-called T and B cells expressing greater than 109 different T- or B-cell hapten-carrier complex, this modified protein can induce an immune receptors for antigen (TCR, BCR). The enormous polymor- response. This concept has recently been supplemented by the p-i phism of the immune system allows it to react to all kinds of concept (or pharmacological interaction with immune receptors), different antigens and even to a