原创力文档the pi3k–nf-κb signal transduction pathway is involved in mediating the anti-inflammatory effect of ib-meca in adjuvant-induced arthritispi3k-nf-κb信号转导通路参与调停ib-meca在adjuvant-induced关节炎的抗炎效果.pdfVIP
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the pi3k–nf-κb signal transduction pathway is involved in mediating the anti-inflammatory effect of ib-meca in adjuvant-induced arthritispi3k-nf-κb信号转导通路参与调停ib-meca在adjuvant-induced关节炎的抗炎效果
Available online /content/8/1/R33
Vol 8 No 1 Open Access
Research article
The PI3K–NF-κB signal transduction pathway is involved in
mediating the anti-inflammatory effect of IB-MECA in
adjuvant-induced arthritis
1,2 1,2 1 3 1
Pnina Fishman , Sara Bar-Yehuda , Lea Madi , Lea Rath-Wolfson , Avivit Ochaion ,
Shira Cohen1 and Ehud Baharav2
1Can-Fite BioPharma Ltd., Kiryat-Matalon, Petah-Tikva, Israel
2Felsenstein Medical Research Center, Rabin Medical Center, Sackler Faculty of Medicine Tel-Aviv University, Petach-Tikva, Israel
3Department of Pathology Rabin Medical Center, Sackler Faculty of Medicine Tel-Aviv University, Petach-Tikva, Israel
Corresponding author: Pnina Fishman, pnina@canfite.co.il
Received: 5 Jun 2005 Revisions requested: 14 Jul 2005 Revisions received: 5 Dec 2005 Accepted: 15 Dec 2005 Published: 13 Jan 2006
Arthritis Research Therapy 2006, 8:R33 (doi:10.1186/ar1887)
This article is online at: /content/8/1/R33
© 2006 Fishman et al, licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
The anti-inflammatory effect of adenosine was previously found necrosis factor alpha, known to affect survival and apoptosis of
to be mediated via activation of the A3 adenosine receptor inflammatory cells, whereas the caspase-3 level was
(A3AR). The aim of the present study
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