原创力文档the phosphatidylinositol 3-kinasemtor pathway as a therapeutic target for brain aging and neurodegeneration磷脂酰肌醇的3-kinasemtor通路作为大脑衰老和神经退行性变的治疗目标.pdfVIP
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the phosphatidylinositol 3-kinasemtor pathway as a therapeutic target for brain aging and neurodegeneration磷脂酰肌醇的3-kinasemtor通路作为大脑衰老和神经退行性变的治疗目标
Pharmaceuticals 2011, 4, 1070-1087; doi:10.3390/ph4081070
OPEN ACCESS
pharmaceuticals
ISSN 1424-8247
/journal/pharmaceuticals
Review
The Phosphatidylinositol 3-Kinase/mTor Pathway as a
Therapeutic Target for Brain Aging and Neurodegeneration
David Heras-Sandoval, Evangelina Avila-Muñoz and Clorinda Arias *
Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones
Biomédicas, Universidad Nacional Autónoma de México, 04510, México D.F., Mexico;
E-Mails: david.herassandoval@ (D.H.-S.); ediacaraart@.mx (E.A.-M.)
* Author to whom correspondence should be addressed; E-Mail: carias@unam.mx;
Tel.: +52-55 Fax: +52-55
Received: 12 May 2011; in revised form: 22 July 2011 / Accepted: 28 July 2011 /
Published: 4 August 2011
Abstract: Many pathological conditions are associated with phosphatidylinositol 3-kinase
(PI3K) dysfunction, providing an incentive for the study of the effects of PI3K modulation
in different aspects of diabetes, cancer, and aging. The PI3K/AKT/mTOR pathway is a key
transducer of brain metabolic and mitogenic signals involved in neuronal proliferation,
differentiation, and survival. In several models of neurodegenerative diseases associated
with aging, the PI3K/AKT pathway has been found to be dysregulated, suggesting that two
or more initiating events may trigger disease formation in an age-related manner. The
search for chemical compounds able to modulate the activity of the PI3K/AKT/mTOR
pathway is eme
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