the pharmacological effects of morroniside and loganin isolated from liuweidihuang wan, on mc3t3-e1 cellsmorroniside的药理作用和马钱子苷liuweidihuang wan隔绝,在mc3t3-e1细胞.pdfVIP

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the pharmacological effects of morroniside and loganin isolated from liuweidihuang wan, on mc3t3-e1 cellsmorroniside的药理作用和马钱子苷liuweidihuang wan隔绝,在mc3t3-e1细胞.pdf

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the pharmacological effects of morroniside and loganin isolated from liuweidihuang wan, on mc3t3-e1 cellsmorroniside的药理作用和马钱子苷liuweidihuang wan隔绝,在mc3t3-e1细胞

Molecules 2010, 15, 7403-7414; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article The Pharmacological Effects of Morroniside and Loganin Isolated from Liuweidihuang Wan, on MC3T3-E1 Cells Manyu Li, Wei Wang, Ping Wang, Kun Yang, Hui Sun and Xijun Wang * National TCM Key Lab of Serum Pharmacochemistry, Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin 150040, China * Author to whom correspondence should be addressed; E-Mails: phar_research@ or wxj@. Tel. Fax: +86-451-8211-0818. Received: 6 September 2010; in revised form: 18 October 2010 / Accepted: 19 October 2010 / Published: 21 October 2010 Abstract: Liuweidihuang Wan (LW), initially a well-known formula for curing “wu chi wu ruan”, is commonly used nowadays for clinical treatment of Postmenopausal Osteoporosis (PO), but the identity of the effective substance(s) remains unclear. The present study was designed to evaluate the effects of morroniside and loganin isolated from LW on the proliferation, differentiation and apoptosis of MC3T3-E1 cells, as well as the possible mechanism of action. Morroniside and loganin had no effects on the proliferation of MC3T3-E1 cells, but both susbtances could improve the activity of alkaline phosphatase (ALP), and increase the contents of collagen type I and osteocalcin. Simultaneously, the mRNA expression of caspase-3, capase-9, RANKL was down-