the regulatory repertoire of pseudomonas aeruginosa ampc ？-lactamase regulator ampr includes virulence genes监管的铜绿假单胞菌ampc 内酰胺酶调节器ampr包括毒性基因.pdfVIP

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the regulatory repertoire of pseudomonas aeruginosa ampc ？-lactamase regulator ampr includes virulence genes监管的铜绿假单胞菌ampc 内酰胺酶调节器ampr包括毒性基因.pdf

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the regulatory repertoire of pseudomonas aeruginosa ampc ？-lactamase regulator ampr includes virulence genes监管的铜绿假单胞菌ampc 内酰胺酶调节器ampr包括毒性基因

The Regulatory Repertoire of Pseudomonas aeruginosa AmpC ß-Lactamase Regulator AmpR Includes Virulence Genes 1 2 3¤a 3¤b 4 Deepak Balasubramanian , Lisa Schneper , Massimo Merighi , Roger Smith , Giri Narasimhan , 3 2 Stephen Lory , Kalai Mathee * 1 Department of Biological Sciences, College of Arts and Science, Florida International University, Miami, Florida, United States of America, 2 Molecular Microbiology and Infectious Diseases (Herbert Werthiem College of Medicine), Florida International University, Miami, Florida, United States of America, 3 Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachussetts, United States of America, 4 School of Computing and Information Science, College of Engineering and Computing, Florida International University, Miami, Florida, United States of America Abstract In Enterobacteriaceae, the transcriptional regulator AmpR, a member of the LysR family, regulates the expression of a chromosomal b-lactamase AmpC. The regulatory repertoire of AmpR is broader in Pseudomonas aeruginosa, an opportunistic pathogen responsible for numerous acute and chronic infections including cystic fibrosis. In addition to regulating ampC, P. aeruginosa AmpR regulates the sigma factor AlgT/U and production of some quorum sensing (QS)- regulated virulence factors. In order to better understand the ampR regulon, we compared the transcriptional profile generated using DNA microarrays of the prototypic P. aeruginosa PAO1 strain with its isogenic ampR deletion mutant, PAODa