the role of dendritic cells in the pathogenesis of systemic lupus erythematosus树突状细胞的作用在系统性红斑狼疮的发病机制.pdfVIP

Fransen et al. Arthritis Research Therapy 2010, 12:207 /content/12/2/207 R E V I E W The role of dendritic cells in the pathogenesis of systemic lupus erythematosus 1 1 1 2 1 1 Justin H Fransen , Johan van der Vlag , Jurjen Ruben , Gosse J Adema , Jo H Berden and Luuk B Hilbrands* of the autoimmune T helper (h ) cells requires immuno- Abstract genic antigen presentation by dendritic cells (DCs) [5]. The etiology of the autoimmune disease systemic Here, we provide an overview of the role of DCs and their lupus erythematosus is not known, but aberrant response to apoptotic material in the pathogenesis of SLE. apoptosis and/or insuicient clearance of apoptotic material have been assigned a pivotal role. During Dendritic cells apoptosis, nucleosomes and several endogenous At the interface of innate and adaptive immunity, DCs danger-associated molecular patterns are incorporated play a pivotal role in the regulation of immune responses. in blebs. Recent data indicate that apoptotic blebs DCs are distributed throughout the body for optimal induce maturation of myeloid dendritic cells, antigen capture and, as the most potent antigen resulting in IL-17 production by T cells. In this review presenting cells, they are well suited to activate (naïve) we summarize current knowledge on the role of T cells. On the other hand, immature DCs can promote dendritic