the role of neutrophils during mild and severe influenza virus infections of mice中性粒细胞的作用在轻微和严重的流感病毒感染的老鼠.pdfVIP
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the role of neutrophils during mild and severe influenza virus infections of mice中性粒细胞的作用在轻微和严重的流感病毒感染的老鼠
The Role of Neutrophils during Mild and Severe
Influenza Virus Infections of Mice
1 1 2 1 1
Michelle D. Tate , Lisa J. Ioannidis , Ben Croker , Lorena E. Brown , Andrew G. Brooks , Patrick C.
Reading1,3*
1 Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia, 2 Walter and Eliza Hall Institute of Medical Research, Melbourne,
Victoria, Australia, 3 WHO Collaborating Centre for Reference and Research on Influenza, North Melbourne, Victoria, Australia
Abstract
Neutrophils have been implicated in both protective and pathological responses following influenza virus infections. We
have used mAb 1A8 (anti-Ly6G) to specifically deplete LyG6high neutrophils and induce neutropenia in mice infected with
virus strains known to differ in virulence. Mice were also treated with mAb RB6-8C5 (anti-Ly6C/G or anti-Gr-1), a mAb widely
used to investigate the role of neutrophils in mice that has been shown to bind and deplete additional leukocyte subsets.
Using mAb 1A8, we confirm the beneficial role of neutrophils in mice infected with virus strains of intermediate (HKx31;
H3N2) or high (PR8; H1N1) virulence whereas treatment of mice infected with an avirulent strain (BJx109; H3N2) did not
affect disease or virus replication. Treatment of BJx109-infected mice with mAb RB6-8C5 was, however, associated with
significant weight loss and enhanced virus replication indicating that other Gr-1+ cells, not neutrophils, limit disease severity
during mild influenza infections.
Citation: Tate MD, Ioannidis LJ, Croker B, Brown LE, Brooks AG, et al. (2011) The Role of Neutrophils during Mild and Severe Influenza Virus Infections of
Mice. PLoS ONE 6(3): e17618. doi:10.1371/journal.pone.0017618
Editor: Ron
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