the role of osteopontin (opnspp1) haplotypes in the susceptibility to crohn's disease骨桥蛋白的作用(opnspp1)单在克罗恩病的易感性.pdfVIP
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the role of osteopontin (opnspp1) haplotypes in the susceptibility to crohn's disease骨桥蛋白的作用(opnspp1)单在克罗恩病的易感性
The Role of Osteopontin (OPN/SPP1) Haplotypes in the
Susceptibility to Crohn’s Disease
¨ 1,2,3. 1. 2 4 1,2 1
Jurgen Glas , Julia Seiderer , Corinna Bayrle , Martin Wetzke , Christoph Fries , Cornelia Tillack ,
1,5 1 1 1,2 1,2
Torsten Olszak , Florian Beigel , Christian Steib , Matthias Friedrich , Julia Diegelmann , Darina
6 1
Czamara , Stephan Brand *
1 Department of Medicine II - Grosshadern, Ludwig-Maximilians-University, Munich, Germany, 2 Department of Preventive Dentistry and Periodontology, Ludwig-
¨
Maximilians-University, Munich, Germany, 3 Department of Human Genetics, Rheinisch-Westfalische Technische Hochschule (RWTH), Aachen, Germany, 4 Department of
Pediatrics, Hannover Medical School, Hannover, Germany, 5 Division of Gastroenterology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts,
United States of America, 6 Max-Planck-Institute of Psychiatry, Munich, Germany
Abstract
Background: Osteopontin represents a multifunctional molecule playing a pivotal role in chronic inflammatory and
autoimmune diseases. Its expression is increased in inflammatory bowel disease (IBD). The aim of our study was to analyze
the association of osteopontin (OPN/SPP1) gene variants in a large cohort of IBD patients.
Methodology/Principal Findings: Genomic DNA from 2819 Caucasian indi
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