the sirt1 deacetylase suppresses intestinal tumorigenesis and colon cancer growthsirt1的脱乙酰酶抑制肠道肿瘤发生和结肠癌的增长.pdfVIP

The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth 1,3,4,6. 2.¤b 1. 1 3,4 Ron Firestein , Gil Blander , Shaday Michan , Philipp Oberdoerffer , Shuji Ogino , Jennifer 1 2 1¤a 5 6 Campbell , Anupama Bhimavarapu , Sandra Luikenhuis , Rafael de Cabo , Charles Fuchs , William C. 6 2 1 Hahn , Leonard P. Guarente , David A. Sinclair * 1 Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America, 2 Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, 3 Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, 4 Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, 5 Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America, 6 Department of Medical Oncology, Dana Farber Cancer Institute, and Broad Institute of Harvard and Massachusetts Institute of Technology, Boston, Massachusetts, United States of America Abstract Numerous longevity genes have been discovered in model organisms and altering their function results in prolonged lifespan. In mammals, some have speculated that any health benefits derived from manipulating these same pathways mig