热分析法测定固体药物的多晶型（Determination of polymorphs of solid drugs by thermal analysis）.doc

热分析法测定固体药物的多晶型（Determination of polymorphs of solid drugs by thermal analysis） Determination of polymorphs of solid drugs by thermal analysis First, the purpose of the experiment 1. familiar with the basic principles and experimental methods of thermal analysis and their main applications in pharmaceutical research 2. master the methods of analysis of thermal spectra and determination of polymorphs 3. understand the main structure of the thermal analyzer Two. Basic principles Thermal analysis is a technique that measures the physical and chemical properties of a substance as a function of temperature under program temperature control. Program temperature control may use linear, logarithmic or reciprocal procedures. The thermal analysis method in accordance with the measured physical properties of different samples are the following: differential thermal analysis, differential scanning calorimetry, thermogravimetric analysis, thermal analysis and thermal stress analysis, extensive application of three technology in drug research. Differential thermal analysis (I) Differential thermal analysis (differential, thermal, analysis, DTA) is a technique to measure the temperature difference between a substance and a reference in terms of temperature or time under programmed temperature control. According to the International Association of thermal analysis (International Confederation for thermal analysis, ICTA), DTA peak curve upward, the endothermic peak down, sensitivity unit for microvolt (V). Figure 1-1 picric acid (three nitro phenol) DTA curve. The DTA curve of 1-1 in dynamic picric acid in the air Obviously, in the system of temperature control procedures, continuous heating or cooling, the material will be in accordance with the law of motion of its inherent and quantitative or qualitative change, resulting in endothermic or exothermic and endothermic or exothermic change can be determined according to the intrinsic nature of the material. For example, crystal trans