糖皮质激素治疗急性视神经炎的研究进展（Research progress of glucocorticoid in the treatment of acute optic neuritis）.doc

糖皮质激素治疗急性视神经炎的研究进展（Research progress of glucocorticoid in the treatment of acute optic neuritis） Research progress of glucocorticoid in the treatment of acute optic neuritis [Abstract] the effectiveness of glucocorticoids in the treatment of acute optic neuritis has been controversial, and a number of clinical studies have been carried out in many countries. This article reviews the history, treatment methods, side effects and prognostic factors of acute optic neuritis treated with glucocorticoids, so as to evaluate its therapeutic significance. Keywords acute optic neuritis; corticosteroid; methylprednisolone; dexamethasone; treatment; Abstract The treatment of acute optic neuritis with glucocortico steroid is always controversial, so academician from many countries make a series of clinical trial.We make a review about the history of using glucocorticosteroid to treat acute optic neuritis, the treatment method, side effecs and the influence factors of prognosis to evaluate its effects.  KEYWORDS:, acute, optic, neuritis; glucocorticosteroid; methylprednisolone; treatment; dexamethasone 0 Introduction Acute optic neuritis (AON) is an inflammatory disease of the optic nerve, characterized mainly by acute or subacute visual acuity, retrobulbar pain, visual field defect, and visual evoked potential abnormalities. No significant changes in visual papilla or edema were observed in [1]. Depending on the site of the disease, optic neuritis (neuropapillitis) and retrobulbar neuritis (retrobularneuritis) can be divided into two categories. Optic neuritis is more common in young adults and children, accounting for 86% of patients under 40 years of age. The disease decreased rapidly after 1 to 2wk, and the vision of 1Mo increased gradually after the disease, [2]. The treatment of acute optic neuritis includes oral hormone, retrobulbar injection of hormone and intravenous drop of hormone, immunoglobulin and acupuncture therapy, [3]. 1 causes of acute optic neuritis The etiolo