BCG及其相关组分对哮喘小鼠气道炎症和气道反应性的影响.pdfVIP

，。卅l医学院硕士论文 BcG及其相关组分对哮喘小鼠气道炎症和气道反应性的影响 TheeffectsOfBacmeCalmette—Guerinandit’sextracts0n 0f inflammatiOnand airway airway deVelopment inan mousemodel asthmatic hyperresponsiVeness Abstract PartI Establishmentthemethodfor of airway measuring Ofasthmaticmousemodel respOnSiVeneSS aninVasiVemethod bronchial establish of objeetive：Tb measuring inoValbumin—sensitizedasthmaticmousemodel． hyperresponsiVeness Methods：(1)Amethodof bronchial testing wasassessedaninvasiVe whole AirwayresponsiVenessusing single—chamber obtainedf}omBuxco．Mousewas inthe bodyplethysmograph placed chamberandbaseline measured．Themousewas airwayresistance(RI)was with concentrationsofmethachlineaerosolto200 challengedincreasing up was to resistance wasusedevaluatethe mg／ml，theairway measured．PCIoo bronchial inmethacho】ine oowasdennedas responsiveness challenge，PCI thedoseofmethacholine100％ increaseof causing respiratory valueswere resistance．The convertedinto s钯tistical Pcloo