血管内皮生长因子在异丙肾上腺素诱导大鼠心力衰竭中变化及卡维地洛干预的影响.pdf

increasedimmunohistochemicalofHIF—la．VEGFinthe labeling ventricular WasobservedintheISO myocardium group，PO．01，the intheISO WaS thancontroltoo．P capillarydensity grouphigher group and VEGF、NOincarvedilol O．05．LVEDP,LVW,LVW／BW plasma were to decreased ISO group significantlycomparedgroup，and incarvedilolwereincreased．Theof dp／dtmax、dp／dtmingroup expression Q VEGF．HIF-1andfactorⅧin tissueofcarvedilol lr0 myocardium group also were reduced，and waslessthanthatoflSO density group， capillary whichallthe vailancehasstatistical significance． Conclusions：ThelevelofVEGFin and tissueand plasmamyocardium thenumberof were increasedinISOinduced capillarydensitygreatly heartfailureofrats．andVEGFWascorrelationtoheart function． carl heart Carvedilol functionandreversethe ofVEGF improve change and inISOinducedheartfailure．The capillarydensity experiment thatthe ofheartfailureinvolvethe suggestsdevelopment inductionof