不同解剖部位皮肤斑贴试验结果比较及分析.docVIP

不同解剖部位皮肤斑贴试验结果比较及分析 　作者：陈晶晶　范立英　信许亚　田燕　刘玮　 　　[摘要]目的：比较面部、前臂和背部三个部位同一产品局部封闭式斑贴试验结果的差异。方法：以2006年8月～2006年12月在北京空军总医院化妆品皮肤病专科门诊投诉化妆品过敏的患者为研究对象，判断标准采用《化妆品皮肤病诊断标准及处理原则总则》中的7项化妆品皮肤病诊断国家标准（GB 17149.1～7-1997），统一登记表格记录化妆品皮肤病患者的病史资料及相关化妆品信息，分别在面部、前臂和背部进行同一产品的斑贴试验，对斑试结果进行统计学分析。结果：共112例患者完成了318个产品的斑贴试验，面部阳性反应例数最多，62例（占总患者的55.36%），84个产品(占总产品数的26.42%)；其次为前臂，39例（34.82%），59个产品(18.55%)；背部38例（33.93%），52个产品（16.35%）。面部和背部、面部和前臂斑试结果之间的差异有统计学意义，背部和前臂斑试结果之间的差异无统计学意义。结论：在进行化妆品的斑贴试验中，面部皮肤较前臂和背部敏感。 　　[关键词]斑贴试验；刺激性接触性皮炎；过敏性接触性皮炎；皮肤屏障功能 　　 　　Abstract:ObjectiveTo compare the different results of patch test which applied on face, forearm andback with the same product the patients had used. MethodsThe outpatients with cosmetic dermatosis were collected from Department of Dermatology, Air Force General Hospital between August and December in 2006, according to GB17149. 1～7 - 1997. The patients’ case histories and the suspected cosmetics were recorded. The routine patch tests using the involved cosmetic products were carried out on each patient’s face, forearm and back simultaneously. ResultsTotally, we performed patch tests on 112 patients with 318 products which they had used. The highest rate of positive reaction appeared on the face. There were62 patients (55.36%) and 84 products (26.42%) showed positive reaction on face, 39 patients (34.82%) and 59 products(18.55%) on forearm, 38 patients (33.93%) and 52 products (16.35%) on back. Statistically, there was a significant difference between the results of patch tests applied on face and forearm, between face and back, but no difference between patch tests applied on back and forearm. ConclusionIn cosmetic patch tests, the facial skin is more sensitive than that of forearm and back. 　　Key words: patch test; irritant contact dermatitis; allergic contact dermatitis; skin barrier function 　　 　　斑贴试验能帮助我们寻找致敏化妆品及变应原[1]，其结果对化妆品过敏的诊断和预防都有重要意义。多数化妆品主要用于面部皮肤，而针对投诉化妆品过敏患者进行斑贴试验时，常规选择前臂或背部。当结果呈阴性时，患者常对试验方法表示怀疑，要求在面部进行斑贴试验。在面部、前臂及背部的皮肤进行斑贴试验，其反应有无差别？面部皮肤的