急性缺血性卒中患者PagT及双侧颈内动脉狭窄程度变化.docVIP

急性缺血性卒中患者PagT及双侧颈内动脉狭窄程度变化 　【关键词】 缺血 摘 要：目的：探讨血小板聚集率及颈内动脉狭窄与脑梗塞发病的关系。方法：测定120例急性脑梗塞患者及60例正常人的血小板聚集率(1.5min.MAR),B型多谱勒超声断层扫描检测颅外段颈内动脉狭窄程度。结果：脑梗塞组的血PagT 1min与正常对照组比较有显著差异（Plt;0.05），PagT 5min、MAR与对照组比较有非常显著差异（Plt;0.01）,脑梗塞组B超检测颈内动脉中度以上狭窄占62.5%,正常对照组中度以上狭窄占35%,两组比较有非常显著差异(Plt;0.005)。结论：血小板聚集率升高及颅外段颈内动脉中度以上狭窄,与脑梗塞密切相关。 关键词： 脑梗塞; 血小板聚集率; 颈内动脉狭窄 Variations of Platelet Aggregation Rate and Internal Carotid Artery Stenosis in Patients with Cerebral Infarction Abstract：Objective： To observe the relationship between platelet aggregation rate,internal carotid artery stenosis and occurrence of cerebral infarction.Method: The platelet aggregation test(PagT 1min,PagT 5min,MAR)and levels of the external cervical segment of internal carotid artery stenosis detected by B type ultrasonic tomographic scanning were performed in 120 cases of cerebral infarction patients and 60 normal controls. Result: There was significant difference between patients and controls in the PagT 1min(Plt;0.05).The differences of PagT 5min and MAR between the two groups were very significant(Plt;0.01).The occurrence rate of internal carotid stenosis above the mediate level is 62.5% while the rate is 35% in the controls. There was very significant difference between two groups (Plt;0.005).Conclusion： The increase of platelet aggregation rate and stenosis of the external cervical segment of the internal carotid artery above the mediate level are related to the occurrence of cerebral infarction. Key words： Cerebral infarction; Platelet aggregation rate; Internal carotid artery stenosis 脑血管疾病是当今威胁人类健康和生存的三大主要疾病之一,在各类脑血管疾病中,脑梗塞(cerebral infarction,CI)占60%～80%［1］。我们对住院的120例急性脑梗塞患者及60例健康体检者进行血小板聚集率的变化及颅外段颈内动脉狭窄程度与脑梗塞发病的关系。 1 资料和方法 1.1 对象：急性脑梗塞(CI)组:120例均为我院1999年1月2003年12月住院患者,其中男60例,女60例,年龄46～78岁,平均年龄65±9岁。全部病例均符合1995年第四届全国脑血管病学术会议制定的标准,且均为头颅CT所证实。所有病例均为第一次发病,且为单侧颈内动脉系统脑梗塞,其中脑叶梗塞者32例,基底节梗塞者88例;正常对照组:60例,男29例,女31例,年龄45～76岁,平均年龄63±9岁,为健康体检者(平时不服药),排除血液流变学及血小板功能异常者。两组经统计学分析年龄/性别差异无显著性。两组受检者在测定前15d均未服或停服影响血小板聚集的