曲唑酮及氟西汀治疗抑郁症对照探究.docVIP

曲唑酮及氟西汀治疗抑郁症对照探究 　作者： 万予新 李梅香 韩 嫣 马振武 【关键词】 抑郁症；曲唑酮；氟西汀；汉密尔顿抑郁量表 　　【摘要】 目的 比较曲唑酮与氟西汀治疗抑郁症的疗效及安全性。 方法 将65例抑郁症患者随机分为两组，研究组33例，给予曲唑酮50～200mg#12539;d-1治疗，对照组32例给予氟西汀20#12539;40mg#12539;d-1治疗，观察6w，采用汉密顿抑郁量表、汉密尔顿焦虑量表、临床总体印象量表、副反应量表评定临床疗效及不良反应。 结果 治疗6w末，两组各量表评分均较治疗前有显著改善（P＜0.01），研究组治疗1w末比对照组改善显著（P＜0.05），提示研究组起效快。研究组显效率为75.8%，有效率为93.9%，对照组分别为75.0%和90.6%，两组疗效相当（P＞0.05）。两组不良反应均较轻微，无需特殊处理。 结论 曲唑酮治疗抑郁症疗效显著，安全性高，依从性好。 【关键词】 抑郁症；曲唑酮；氟西汀；汉密尔顿抑郁量表 A controlled study of trazodone vs. fluoxetine in the treatment of depression 【Abstract】 Objective To compare the curative effects and safety of trazodone vs. fluoxetine in the treatment of depression. Methods 65 depressive patients were divided into research group(n=33, took trazodone 50~200mg/d) and control group(n=32,did fluoxetine 20~40mg/d) for 6 weeks. The curative effects and adverse reactions were assessed with the HAMD, HAMA, CGISI and TESS respectively. Results After 6 week treatment, there were significant improvement in scores of all scales compared with pretreatment(P＜0.01);at the end of 1st week improvement was significant in the research group than in the control group(P＜0.05), which hinted that the research group took effects faster. Effectual and effective rates of trazodone group were 75.8% and 93.9% and of fluoxetine group 75% and 90.6%, respectively (P＞0.05). The curative effects of the 2 groups were equivalence(P＞0.05). The adverse reactions of both groups were milder and didnt need special handling. Conclusion Tazodone has an marked curative effect, higher safety and better compliance. 【Keywords】 Depression; trazodone; fluoxetine; HAMD 曲唑酮［1］作为一种新型抗抑郁剂，可选择性地抑制5羟色胺(5HT)和去甲肾上腺素（NE）的再摄取作用，并可阻断组胺H1受体，从而消除抑郁，改善睡眠。具有抗抑郁、抗焦虑［2］、镇静催眠多重作用［3］。为探讨曲唑酮治疗抑郁症的疗效和安全性我们与氟西汀治疗进行了对比研究，现报告如下。 1 资料与方法 1.1 对象 选取2003年3月～2005年12月在我院门诊及住院治疗的65例抑郁症患者为研究对象。入组标准：（1）符合《中国精神障碍分类与诊断标准》第3版（CCMD3）抑郁症诊断标准；（2）汉密顿抑郁量表（HAMD）17项评分＞24分；（3）性别，年龄，病期不限；（4）排除伴有严重躯体疾病、脑器质性疾病、酒及药物依赖者，妊娠、哺乳期妇女等。将入组病例按入院顺序随机分为两组。研究组33例，男16例，女17例，年龄55.42±11.73a，病程6.18±3.45