某农村人群甲、乙、丙、戊及庚型肝炎病毒感染现况探究.docVIP

某农村人群甲、乙、丙、戊及庚型肝炎病毒感染现况探究 　　　【摘要】　目的　了解某农村人群甲、乙、丙、戊和庚型肝炎病毒的感染状况及其流行特点。方法　应用酶联免疫试验(EIA)检测血清抗-HAV、HBsAg、抗-HBs、抗-HBc、抗-HCV、抗-HEV和抗-HGV，并对抗-HGV阳性者应用套式逆转录聚合酶链反应法(RT-nPCR)检测HGV RNA。结果　该人群抗-HAV、抗-HCV、抗-HEV和抗-HGV流行率分别为86.9%、11.5%、2.9%和1.8%，HBsAg阳性率为8.0%，HBV总感染率为54.8%。HAV以5岁以下儿童感染率最低(35.0%)，到10岁时85.0%的儿童已感染HAV。HBsAg阳性率呈现两个高峰，分别在5～9岁和40～49岁年龄组；HBV总感染率到10岁时为55.0%，然后随年龄增长而上升。HCV感染主要集中在20～49岁年龄组(占77.8%)。各型肝炎病毒男女感染率无明显差异。献浆次数、年限与HCV、HEV、HGV感染呈正相关。HBsAg、抗-HBc、抗-HCV呈现家庭聚集性，但仅HBsAg呈现母亲与子女相关。抗-HCV阳性者中ALT异常率(15.9%)显著高于抗-HCV阴性者(1.2%，P＜0.01)。结论　该人群甲、乙、丙、戊和庚型肝炎病毒感染具有不同的流行病学特点；献血浆是该人群HCV、HEV和HGV感染的主要危险因素；抗-HCV阳性者多伴有肝损害。 A cross-sectional study on HAV,HBV,HCV,HEV and HGV infection in a rural population 　　【Abstract】　Objective　To study the epidemiological characteristics of HAV,HBV,HCV,HEV and HGV infections in a rural population. Methods　Enzyme immunoassays were used for detection of anti-HAV,HBsAg,anti-HBs,anti-HCV,anti-HEV and anti-HGV. Anti-HGV positive sera were further tested for HGV RNA using a reverse transcription nested PCR. Results　The prevalence rates of anti-HAV,HBsAg,anti-HCV,anti-HEV,anti-HGV in the studied population were 86.9%,8.0%,11.5%,2.9% and 1.8%,respectively. The total infection rate of HBV was 54.8%. The HAV infection rate of children below 5 was the lowest (35.0%) as compared with other age groups.amp;n bsp;85.0% of children at 10 years old had already been infected with HAV. The HBsAg positive rate showed two peaks at 5-9 and 40-49 age groups. The total infection rate of HBV was 55.0% in the age group less than 10 years old and increased with age. HCV infection mainly occurred in the age group of 20-49 (77.8%). The prevalence rates of anti-HCV,anti-HEV and anti-HGV increased with the frequencies and duration of plasma donation. Family clusterings of HBsAg,anti-HBc and anti-HCV were observed. However,only with HBsAg showed a correlation between mothers and their offspring.The frequency of abnormal　ALT in anti-HCV　positive individuals was significantly higher as com