珍芪滴眼液治疗慢性结膜炎疗效观察.docVIP

珍芪滴眼液治疗慢性结膜炎疗效观察 　 ;作者：张海娟，马科，张玲，梁庆丰，接英 【摘要】; 目的 观察并分析珍芪滴眼液对慢性结膜炎的临床疗效。方法 入选120例慢性结膜炎患者，随机分入珍芪滴眼液治疗组和珍珠明目滴眼液对照组，采用单盲试验方法，结膜囊滴眼用药，每日4次，连续4周。分别于治疗前、治疗后每周观察患者眼部自觉症状和体征，并按分级量化标准评分。结果 患者用药4周后评定疗效，珍芪滴眼液组治疗慢性结膜炎的总有效率为81.67%、改善中医证候的总有效率为93.33%，珍珠明目滴眼液组分别为70%、83.33%，两组差异无统计学意义（Pgt;0.05）。结论 珍芪滴眼液对慢性结膜炎有较好的治疗作用，有望成为新药用于临床。 【关键词】; 珍芪滴眼液；慢性结膜炎；中医药疗法；临床观察 ; 〔Ａｂｓｔｒａｃｔ〕 Ｏｂｊｅｃｔｉｖｅ To observe and analyze the effect of Zhenqi eye drops on chronic conjunctivitis. Methods The 120 patients with chronic conjunctivitis were randomly divided into treatment group(Zhenqi eye drops) and positive control group(Zhenzhu　Mingmu eye drops) with single blind test. The eye drops were given 4 times a day for 4 weeks. The symptoms, physical signs of the eyes were observed in 7th, 14th and 28th days before and after treatment. Scores were judged and recorded. Results The curative effects were evaluated after 4 weeks, and the effective rate for treatment of the disease was 81.67% and for improvement of traditional Chinese medicine symptoms was 93.33% in treatment group; the effective rate for treatment was 70% and for improvement of traditional Chinese medicine symptoms was 83.33% in positive control group. The difference between two groups was not significant（Pgt;0.05）. Conclusion Zhenqi eye drops is effective for chronic conjunctivitis, and may be a new drug for the disease in clinic. ; 〔Ｋｅｙ ｗｏｒｄｓ〕 Zhenqi eye drops; chronic conjunctivitis; Chinese herbs therapy ; 慢性结膜炎为眼科常见病[1]，患者自觉眼部干涩痒痛，视力疲劳，严重影响了日常生活和学习工作，目前临床尚无特效疗法，常用抗生素、维生素类眼药水和收敛剂治疗，疗效并不显著。珍芪滴眼液为治疗慢性结膜炎的纯中药滴眼液，北京同仁医院院内制剂，批准文号：京药制字。本研究采用随机单盲法，以珍珠明目滴眼液为对照，观察其治疗慢性结膜炎的临床疗效。 ; 1 资料与方法 ; 1.1; 临床资料 ; 全部病例120例均为2005年8月至2005年10月符合诊断标准的慢性结膜炎病人，随机分为珍芪滴眼液组（治疗组）和珍珠明目滴眼液组（对照组）。治疗组60例，其中男30例，女30例，年龄18~65岁，平均（42.43±13.39）岁；病程1个月至6年，平均（1.17±0.93）年；慢性结膜炎症状平均积分（8.28±2.81）分，中医证候平均积分（7.17±2.59）分。对照组60例，其中男27例，女33例，年龄20~62岁，平均（39.47±14.02）岁；病程1个月至3年，平均（1.01±0.72）年；慢性结膜炎症状平均积分（7.62±2.35）分；中医证候平均积分（6.50±2.16）分。两组性别、年龄、病程、慢性结膜炎症状及中医证侯积分比较，差异均无统计学意义（Pg