膀胱移行细胞癌微血管密度及其复发关系.docVIP

膀胱移行细胞癌微血管密度及其复发关系 　【摘要】 目的：探讨肿瘤微血管形成能力与膀胱移行细胞癌复发的关系及机制。方法：采用免疫组化的方法对42例膀胱移行细胞癌组织中的第Ⅷ因子相关抗原，碱性成纤维细胞生长因子（bFGF）及血管内皮细胞生长因子（VEGF）分别进行特异染色，记数肿瘤内微血管密度（MVD），并观察bFGF、VEGF的表达。结果：VEGF和bFGF的阳性表达率分别为：59.5％和40.5％，MVD阳性表达组显著高于阴性表达组（Plt;0.05），术后复发组显著高于未复发组（Plt;0.05），且高MVD组复发率高于低MVD组（Plt;0.05）。结论：MVD与膀胱移行细胞癌复发有关，而且血管形成因子的异常表达是其微血管形成能力增高的重要因素。 【关键词】 膀胱癌；血管内皮细胞生长因子；碱性成纤维细胞生长因子；微血管密度；复发 　　Relation between Microvascular Density and Recurrence in Primary Transitional Cell Carcinoma of Bladder 　　QIU Guoguang,LEI Deli 　　(The 161st Hospital of PLA, Wuhan, Hubei 430010, China;Pu’ai Hospital of Wuhan, Wuhan, Hubei 430022, China) 　　Abstract: Objective To elucidate the expression and significance of vascular endothelial growth factor(VEGF)，basic fibroblast growth factor(bFGF)and the microvascular density (MVD)in primary transitional cell carcinoma of bladder ，and to determine their magnitude of angioenesis. Methods Specimens form 42 patients with primary transitionalcel cell carcinoma of bladder were assayed using immunohistochenmical technique to examine the expression of factor Ⅷ related ：antigen ，basic fibroblast growth factor (bFGF)and vascular endothelial growth factor(VEGF)，as well as the microvascular density (MVD). Results He positive expression rate of VEGF and bFGF was 59.5% and 40.5% ，and the (Plt;0.05) and the recurrence rate of the high MVD group is higher than that of the low MVD(Plt;0.05).The MVD of the recurrence group is higher than that of the non –recurrence group (Plt;0.05)，and the recurrence rate of the high MVD group is higher than that of the low MVD group is higher than that of the low MVD group (Plt;0.05). Conclusion MVD is related with the recurrence of primary transitional cell carcinoma of bladder，and the abnormal expression of vascular endothelial growth factor(VEGF)is the major element in increasing forming capability of the microvascular. 　　Key words: Bladder cancer; Vascular endothelial growth factor (VEGF); Basic fibroblast growth factor(bFGF); Microvascula