早期丰富及贫瘠环境对成年雌雄大鼠恐惧条件化及消退影响.pdf

中，仅贫瘠环境组大鼠消退速度显著降低。5．早期生长环境的差异并不影响声音诱发 的非特异性僵直反应，也不影响自发活动和足部电击敏感性。 结论：早期生长环境的差异并不影响成年雌雄大鼠条件化恐惧反应的获得，但 影响24小时后条件化恐惧反应的再现及随后的恐惧消退学习，且存在性别差异。 关键词： 恐惧条件化， 消退， 僵直， 丰富环境， 贫瘠环境， 自发活动， 足部电击敏感性 4 Theeffectsof enrichedandisolatedenvironmentsonfear early anndeextinction‘nctiOninaIdultultmalemaandfemalema itioning conditioning ABSTRACT environmentscanaffect and adultindividual． Object：Earlyrearing learningmemo巧in Inthe Fear was to the presentexperiment,PavlovianConditioningparadigmadoptedstudy effectsofdifferent conditionsOllfear andextinctioninaduR earlyrearing conditioning maleandfemalemrs． Methods：Environmentaltreatment：Weanedratswere three rearedin manipulable andisolated 8 ratsare11 environments(enriched,socialconditions)．Afterweeks(when weeks test measure：Beforethebehavioralwere old)，behavioral test，rats began．W．eight test：After12weeks，locomoter weighted．Locomoteractivity by distanceand tested．Fear andextinction：Ratsreceivedatone crossing)wasconditioning 24hr an cuedfear sessionafterthelocomotertest．Ratsreceived conditioning activity extinctionsessionandtwoextinctiontestsessions and72hrafter training 24hr．48 Wasassessed all conditioningrespectively．Percentfreezing during test：Ratsreceived f