K-ras基因突变和PTEN蛋白表达对用Cetuximab治疗中国晚期大肠癌患者预后影响.pdfVIP

英文摘要 ofKRASmutationandPTEN on Impact proteinexpression surViValofChinesemetastaticcolorectaI cancer patients treatedwithcetuximab Li Postgraduate： Fang—hua Pro佗ssorXuRui．hua Supervisor： Medical M萄or： Oncology ABSTRACT 1．BACKGROUND the Colorectal secondcauseofcancerdeathboth cancer(CRC)is intheUhitedStatesandinthe itsincidence EuropeanUnion，where is eaCh thelast increasingyear．In t、Ⅳen妙years，significant haVebeenmadeintreatmentofCRC．These improVements signilFicant are aresultofthe Of improVementsmainly deVelopment newcombinationsofstandard fluorouracil， chemotherapyincIuding irinotecan，andandalsonew agents oxaliplatin ther印euticta唱eting moleculareVentsinVolVedincolorectal ofthe carcinogenesis．One most is factor promisingta略etsthe印idennalgrowth receptor isactiVatedincolorectal the (EGFR)，which carcinogenesisby ofa ontheextracellularofit． bindingligand