苯那普利对2型糖尿病病人胰岛素敏感性的影响（Effect of benazepril on insulin sensitivity in patients with type 2 diabetes mellitus）.docVIP

苯那普利对2型糖尿病病人胰岛素敏感性的影响（Effect of benazepril on insulin sensitivity in patients with type 2 diabetes mellitus） Effect of benazepril on insulin sensitivity in patients with type 2 diabetes mellitus 2011-02-28 Chen Shaohua, Fu Lihua, Liu Yunling, Lin Yanpeng, Sun Yuping, Xiao Lingfeng Benazepril is an angiotensin converting enzyme inhibitor (ACEI), mainly used in the treatment of cardiovascular diseases. For diabetes, it protects the kidneys, controls the development and development of proteinuria, and reduces kidney complications. Recently, it has been reported that benazepril affects glucose tolerance in patients with type 2 diabetes mellitus, promotes glycemic control, and speculates that it can improve insulin resistance in the patient [1], but there is no direct evidence for this. To investigate the effect of oral benazepril on insulin sensitivity in type 2 patients, we carried out the following clinical observations. First, objects and methods 1.: for outpatient, hospital in Qianfo Hill province Jinan area and central hospital ward in 42 cases of patients with type 2 diabetes, accord with the diagnostic standard of WHO, there were 29 males and 13 females, mean age 53 + 8 years old, the average duration of 6.5 + 3.7 years, average 25.2 + 1.9 BMI, both with a sulfonylurea, combined treatment of biguanides and poor glycemic control. Patients with cerebrovascular diseases, coronary heart disease, hypertension, neuropathy and nephropathy were 12, 13, 11, 6 and 7, respectively. 2. methods: the original design of 44 cases of patients were used to maintain the original oral antidiabetic drugs (Minidiab or gliclazide plus metformin) and diet, activity does not change, according to the fasting blood glucose level were randomly divided into two groups, 22 cases in each group, one group was treated with benazepril (Lotensin, Beijing Novartis Pharma Ltd) 10mg once a day, after 30 days, another group of blank control. Short term insulin tolerance test before and after 30 days,