结肠黑变病（Melanosis coli）.docVIP

结肠黑变病（Melanosis coli） Melanosis coli (melanosiscoli, MC) is a kind of digestive tract of the black refers to the emergence of colon mucosa in the amount of lipofuscin like substances with phagocytosis of macrophages, the mucosal pigmented lesions, non inflammatory, benign and reversible lesions. The main symptoms are constipation, diarrhea, abdominal pain, abdominal distension, anal swelling, etc., and may be associated with hyperpigmentation, inflammation and irritation of the enteric nervous system. The etiology, pathogenesis and pigment sources are not clear. Most of them are related to long-term constipation. It has been attached importance to because of its frequent colon tumor. Edit the diagnostic criteria for this paragraph Diagnostic criteria for MC Melanosis coli The mucosa of the colon is black, brown or dark gray, and the margins and early lesions are yellow or pink, with tiger skin like, areca cut or patchy. Histological examination showed that large amounts of melanin containing mononuclear cells and black deposits were found in the membranes of the normal membranes, and the other layers of the intestinal wall were normal. Diagnostic criteria for constipation 12 months at least 12 weeks continuous or intermittent following 2 or 2 or more symptoms: 1/4 over time strenuous defecation; the time above 1/4 stools mass or induration; the 1/4 over time with endless sense; the 1/4 time defecation of anal obstruction or anorectal ileus; the above 1/4 time help defecation need manipulation; 1/4 above 3 times weekly defecation time. Edit this paragraph check method Melanosis coli The disease has no specific symptoms and signs, and the diagnosis mainly depends on colonoscopy and pathological examination. For habitual constipation, diarrhea, hematochezia and long-term use of laxatives in patients should be regular colonoscopy, and should be wary of melanosis coli and colonic cancer and polyp canceration. It is thought that the pathogenesis of MC may be related to th