调节致密斑细胞表达COX-2信号传导通路及环孢霉素A影响COX-2表达相关机制的研究.pdf

±里堡塑墨型查兰堡主堕塞皇笙塞 Abstract inthe is in BAKEGROUNDThe apparatuskidneyimportant juxtaglomerular was that isa andreninrelease．It PGE2 extracellularvolume suggested controlling forreninrelease．Inthe theCOX·2 inMD stimulator previousstudy expression potent and thick hasbeenconfirmedtobe ascendinglimb)cells adjacentcTALI-I(cortical inrenal increasedlowsaltdietintakeaswellas areductionperfusionpressure． by by ofNaClatthedistal Inthetwo conditions．theluminalconcentration experimental is tobe is tubularconnectedtotheMD reduced．Therefore，there likely increasing evidencethatCOX-2isall mediatorof function important kidney physiological elementshavebeenidentifiedin possibleregulatory regulation．AlthouI曲numerous MDcellshasbeen ofCOX-2 about 5’-flankingregions genes，fewstudy published．It ofCOX一2and of inthe hasbeenobservedthatthe synthesis expression prostanoid were attenuated