尼莫同对大鼠创伤性脑损伤后脑组织NF-κB表达及活化影响.pdf

尼莫同对大鼠创伤性脑损伤后脑组织NF-κB表达及活化影响.pdf

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afterstrike.Other were same immediately groups injectedquantity normalsalinesamemethod.Thebraintissue in by specimensevery group were atthetimeof respectivelygathered 6h, 24h,48hand96hafter beheadtheratsas as were operationby quicklypossible.Allspecimens fixedin andsliced thecenterof focus. poly-formaldehydethough injury The ofNF—KBP65and inratbrain expression IKBa afterTBlwas detectedwith method,atthesame immunohistochemistry timethe mRNAamountofNF—rBin braintissuewasmeasured byhybridization insitu approach. with Band F,theactivationof [Results]Comparedgroup group NF-KBP65inbraintissuewere increasedin obviously M(P group 0.0 ofitisat24hoursafterstrikeand 1),thepeak lastinghigh expression until96hours. Bothdexamethsoneand CaninhibittheactivationofNF-KB nimotop P65inratbraintissuesafter with M,the TBI.Comparedgroup ofNF—KBinbraintissuein Dand Nwere expression group group with D,theactivation obviouslydecreased(Po.o 1).Comparedgroup ofNF-KBP65 N

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