作用于革兰氏阳性菌的抗生素85126（An antibiotic 85126 that acts on Gram-positive bacteria）.docVIP

作用于革兰氏阳性菌的抗生素85126（An antibiotic 85126 that acts on Gram-positive bacteria） [character] this product is an organic acid, insoluble in water and soluble in organic solvents. Sodium (or potassium) salts are often used in clinic to increase its water solubility [stability] the nature of this product is unstable. Beta lactam ring is the most unstable part of the structure of the compound. It is easy to undergo hydrolysis and ring opening in the presence of acid, alkali or beta lactamase, and lose its antibacterial activity [Nature] No alkali resistance was cleaved for D-, Penicillium, and Penicillium aldehydes. ? not acid at pH=2, decomposition of Penicillium acid; in pH=4, decomposed into penicillenic acid, the molecular rearrangement formation of Penicillium acid, in strong acid condition or mercuric chloride lysis of D- penicillamine and penilloaldehyde. So penicillin cant be taken orally. An enzyme that stimulates Staphylococcus aureus or some other bacteria to produce a substance called beta lactamase The beta lactam ring is opened to ring and lose antimicrobial activity. This is why bacteria tend to be resistant to penicillin Penicillin can not be taken orally, can be prepared into water injection for medicinal use? May not。 Because the beta lactam ring in the penicillin structure is very unstable, the injectable water is easily hydrolyzed and opened to destroy the antibacterial activity. Therefore, it is often made into powder injection and used with Sterile Water for Injection before injection [resistance Role of bacteria] Most gram positive bacteria, such as hemolytic streptococci, pneumococcus, green streptococci, etc.; Gram negative cocci such as Neisseria meningitidis and susceptible Neisseria gonorrhoeae; Let go! bacterium A causative helicoid, such as Treponema pallidum and leptospira. ? Antibacterial action and clinical selection ? The same antibiotics, penicillin, are the synthesis of peptide blocking cells, and can also be combined with different penici