泮立苏（Panlisu）.docVIP

泮立苏（Panlisu） Pantoprazole sodium [name of drug] Pantoprazole sodium English generic name: Pantoprazole Sodium Other name: Fushitan, Innocent, Pan Meilu, Pan Lisu, Taimeinike, pantoloc, Enteric, Enteric-Coated, security, Panmeilu [clinical application] 1., mainly used for peptic ulcers (gastric ulcer, duodenal ulcer, anastomotic ulcer, etc.) and their bleeding, including non steroidal anti-inflammatory drugs caused by acute gastric mucosal damage and stress ulcer bleeding. 2. for reflux esophagitis, also for general anesthesia or major surgery and coma coma patients, to prevent acid reflux combined with aspiration pneumonia. 3. for gastrin. 4., in combination with other antimicrobial agents such as clarithromycin, amoxicillin and metronidazole, eradication of Helicobacter pylori (Hp) infection, reduce duodenal ulcer and gastric ulcer recurrence. [pharmacology] 1. pharmacodynamics, the drug is pantoprazole sodium salt, the action is the same as pantoprazole. Pantoprazole is the third generation of proton pump inhibitor, selectively act on the parietal cells of the gastric mucosa, inhibition of cell wall in H+, K+-ATP enzyme activity, the cell wall within the H+ can not be transported into the stomach, thereby inhibiting gastric acid secretion. Pantoprazole is weakly alkaline, in weak acidic environment was more stable than similar drugs, after being activated only with a proton pump on the activation site two binding sites (omeprazole, lansoprazole and showed more activation and independent binding sites), reflecting the highly selective combined with proton pump at the molecular level. At the same time, it can also reduce the secretion of gastric juice and inhibit pepsin secretion and activity. In addition, this drug inhibits the growth of Hp and can eradicate Hp completely with antibacterial agents. Because the drug has low affinity for cytochrome P450 enzymes and has a phase II metabolic pathway, other drugs that pass through the enzyme system interact less with th