白细胞过滤对心瓣膜置换术病人心肺保护和炎症反应影响.pdfVIP

白细胞过滤对心瓣膜置换木病人心肺保护和炎症反应的影响 of F¨trationon and Effects Clinical Leucocyte MyocardiumLung Depletion and inPatients Valve Protection Response Undergoing Inflammatory Surgery Xiao-Hua Postgraduate：Zhang Xi Supervisor：Prof．Zhang ABSTRACT and Background0bjective main ofthe effectsof The mechanisms cardiopulmonary damaging arereJatedtothe andthe ofbloodtothe ischemia-reperfusionexposure ina inflammatory iSwell extracorporealcircuit．resultingsystemic response．It documentedthat acruciaIrolejnthe Ieucocytes inflammatory play systemic response causedCPBwith of free releasingoxygen-derivedradicals(OFR)and by proteolytic further activationofthe enzymes，with leucocyte．Theleucocyte significant depletion iSoneof methodsto filtration the this duringcardiopulmonarybypass suppress response- iSoneof ofimmunlty seriaIfactor CPB Leucocyte composition system．A during wilI the Ieadsto intefactionsin