第3章：骨干细胞向成骨细胞分化综述.pdf

中国科技论文在线 骨髓间充质干细胞向成骨细胞分化的影响 # 因素 管常东，黄艳，樊瑜波** 5 （北京航空航天大学生物与医学工程学院，生物力学与力生物学教育部重点实验室， 北京 100191 ） 摘要：背景：目前以骨移植为基本理念的骨组织工程在骨损伤临床治疗中被广泛应用，骨髓 间充质干细胞作为骨组织工程研究领域最重要的种子细胞，其向成骨细胞方向分化的诱导成 为该领域的一个研究热点。研究现状：许多研究已经证实了在体外可以诱导骨髓间充质干细 10 胞向成骨细胞方向分化，当前的研究热点集中在该诱导条件的优化，以期体外获得大量性状 稳定的成骨细胞。研究用途：有助于解决骨组织工程中细胞来源的问题，在骨科疾病的临床 治疗领域有重要的研究意义。 关键词：生物医学工程；骨髓间充质干细胞；成骨细胞；分化；生物化学因素；物理因素 中图分类号：R318 15 Influence Factors on Osteogenic Differentiation of Bone Marrow-derived Mesenchymal Stem cells GUAN Changdong, HUANG Yan, FAN Yubo (Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of 20 Biological Science and Medical Engineering, Beihang University, Beijing 100191) Abstract: Background: with the basic concept of bone graft, bone tissue engineering was widely used in the field of bone injury clinical treatment. Bone marrow mesenchymal stem cells (BMSCs) were shown as the most important seed cells of bone tissue engineering, and received extensive attention because they could be induced to differentiate into osteoblasts. Research progresses: 25 many studies have already confirmed that BMSCs could be induced to differentiate into osteoblasts in vitro, nowadays many researchers focus on the optimization of the conditions during the process of induction, in order to get numerous osteoblasts. Research purposes: the aim of those studies were to get enough cells