猪肌肉发育调控与高瘦肉率基因改良猪的研究进展.pdf

Online system: http://www.j 业 生 物 技 术 学 报 Journal of Agricultural Biotechnology 2012, 20(8): 955~964 DOI: 10.3969/j .issn.1674-7968.2012.08.016 评述与展望 Review and Progress 猪肌肉发育调控和高瘦肉率 因改良猪的研究进展 刘楠 阮进学 杨述林* 中国农业科学院北京畜牧兽医研究所，北京 100193 ， * 通讯作者 hi_ysl@ 要 猪肉的产量和质量与肌肉发育过程紧密相关。肌肉发育包括胚胎期肌纤维的形成、出生后肌纤 维的发育和成年期肌肉的再生等步骤，该过程受到转录水平、转录后水平及通路水平等 层次的网络调 控。本文以猪肌肉发育过程为切入点，重点讨论了调控猪肌肉发育的分子 础和高瘦肉率基因改良猪的 研究进展，为进一步培育优质猪肉和高瘦肉率猪品种提供了参考。 关键词 猪，肌肉发育，转录调控，转录后调控，通路调控，转基因猪 Regulation of Porcine Muscle Development and Research Progress of Improved Pigs With High Lean Meat Percentage LIU Nan RUAN Jin-Xue YANG Shu-Lin* Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beij ing 100 193, China * Corresponding author, hi_ysl@ Abstract The production and quality of pork is closely related to muscle development. Muscle development needs to undergo several steps: The formation of prenatal muscle fiber, the differentiation and enlongation of postnatal muscle fiber and the renewal of adult muscle. The myogenesis process is controled by a complicated network, including tanscriptional, post-transcriptional regulation and several pathways. Starting from the process of porcine myogenesis, we will mainly discuss the molecular mechanism of myogenesis regulation and the transgenetic pigs for pork improvement in this review, which will provide the basis for cultivating pigs with high lean meat percentage and obtianing pork of high quality. Keywords Porcine, Myogenesis, Transcriptional regulation, Posttranscriptional regulation, Pathways, Transgenic pigs 肌肉不仅是猪维持正常运动和生理代谢的重 期主要是形成个体的肌肉骨架，出生后是不同肌纤 要器官，更是人类摄取动物蛋白的主要来源。研究 维类型的改变、直径和长度的增加，而成年期是为 猪肌肉的生长发育及调控机制在促进个体生长发 了修复受损肌纤维。 育、提高猪肉的产量和质量、治疗人类肌肉萎缩等 胚胎期的肌肉发育极为重要，有研究表明，肌 方面具有重要意义