中医药联合核苷（酸）类药物治疗慢性乙型病毒性肝炎的研究进展.pdfVIP

国际中医中药杂志2017年1月第39卷第1期 Int J Trad Chin Med, January 2017, Vol. 39, No.1                      ·93 ·  ·综述 · 中医药联合核苷(酸)类药物治疗慢性乙型 病毒性肝炎的研究进展 黄古叶 顾桥 黄国初 【摘要】 通过检索近年来中医药联合核苷(酸)类药物治疗慢性乙型病毒性肝炎(chronic hepatitis B, CHB)的临床、实验类研究文献，从中医药联合核苷(酸)类药物治疗 HBeAg 阳性、HBeAg 阴性、CHB 肝 纤维化、CHB 肝硬化等相关文献进行综述，为中西医结合治疗慢性乙型病毒性肝炎提供参考。 【关键词】 乙型肝炎，慢性；核苷酸，药物；中医药疗法；中西医结合疗法；综述 Review of Studies on the Chinese Medicine combined with Nucleoside (acid) Drugs for Chronic Hepatitis B Huang Guye, Gu Qiao, Huang Guochu. Department of Hepatology, First Affi liated Hospital, Guangxi University of Chinese Medicine, Nanning 530022, China Corresponding author: Huang Guochu, Email: 349661907@ 【Abstract 】 Recent studies showed that Chinese medicine combined with nucleoside (acid) treatments could benefit chronic hepatitis B (CHB). Many patients have gained the benefits from these treatments. This paper summarized the recent studies of Chinese medicine combined with nucleoside (acid) drugs for chronic hepatitis B, and discussed the status of the researches, in order to explore an integrated treatment for chronic hepatitis B. 【Keywords 】 Hepatitis B, Chronic; Aptamers, Nucleotide, Pharmaceutical; Traditional Chinese Medicine therapy; Integrated Chinese traditional and western medicine therapy; Review 慢性乙型病毒性肝炎(chronic hepatitis B, CHB)是由 疗 HBeAg 阳性 CHB 患者 40 例，观察 T 淋巴细胞亚群、 HBV 引起的严重危害人类健康的疾病。据 WHO 公布的 酪 氨 酸 - 蛋 氨 酸 - 天 冬 氨 酸 - 天 冬 氨 酸 数据显示，全球约有 2.4 亿人感染慢性 HBV 、HBeAg (Tyrosine-methionine-aspartate-aspartic acid, YMDD)变异 阳性持续至少 6 个月，每年超过 68.6 万人死于 CHB 并发 株阳性、B 淋巴细胞亚群、外周血瘦素水平的变化情况。 ＋ ＋ ＋ ＋