亚临床甲状腺功能异常与骨质疏松.pdfVIP

·甲状腺疾病专栏· 亚临床甲状腺功能异常与骨质疏松 尹飞 李菲李志红 【摘要】亚临床甲状腺功能异常(STD)和骨质疏松是常见的内分泌疾病，主要发生在女性和老 年人群中。甲状腺激素和促甲状腺激素可直接或间接影响骨代谢，导致骨密度发生变化。而STD患者 体内这两种激素水平异常，提示STD和骨质疏松之间存在一定的联系。此外，外源性甲状腺激素替代 治疗亦可影响骨代谢，导致骨密度下降和骨质疏松。因此，明确STD和骨质疏松之间的联系并采取适 当干预措施对于预防STD患者发生骨质疏松有重要意义。 【关键词】亚临床甲状腺功能减退症；亚临床甲状腺功能亢进症；促甲状腺激素；骨质疏松 and Yin Subclinical Fei，LiFei，Li o／ thyroiddysfunctionosteoporosis Zhihong．Department NO．1Central 071000，China Endocrinology，BaodingHospital，Baoding author：Li Zhihong，Email：lizhihonglfz@126．corn Corresponding subclinical arecommonendocrine 【Abstract】Boththyroiddysfunction(STD)andosteoporosis the hormoneand diseaseswhichaffectfemaleand elderly mainly．Thyroid thyroid—stimulating population affectbonemetabolismor to inboneminerM hormone(TSH)can directlyindirectly，leadingchanges density． Both hormoneand hormoneareabnormdinSTD which an thyroid thyroid—stimulating patients suggests associationbetweenSTDand hormone alsoaffect osteoporosis．Inaddition，thyroidreplacementtherapymay a ofbonemineral and bone in reduction densityosteoporosis．Therefore，uncovering metabolism，resulting the betweenSTDand and interventionto the relationship osteoporosistakingappropriate improverivingquality of withSTDareof patients greatimportanee． words】Subclinical hormone； 【Key hypothyroidism；Subclinicalhyperthyroidism；Thyroid—stimulating Osteoporosis (IntJEndocrinofMeto]D，2015，35：258—260) 亚临床甲状腺功能异常是指只有血清促甲状 外，T3还可通过生长激素和胰岛素样生长因子一