蛋白质O-GlcNAc 糖基化与肿瘤.pdfVIP

肿瘤2013 年11 月第33 卷第11 期　TUM OR Vol. 33, November 2013　　 1027 DOI: 10.3781/j .issn.1000-7431.2013.11.016 Copyright© 2013 by TUM OR Review 综述 · 蛋白质O-GlcNAc糖基化与肿瘤 张肖冰，师以康 山东大学国家糖工程技术研究中心 山东大学药学院，山东济南　250012 [摘要]　单个N- 乙酰葡萄糖胺 （N-acetylglucosamine ，GlcNAc ）在蛋白质的丝氨酸或苏氨酸残基的羟基氧原 子上进行连接称之为蛋白质O-GlcNAc 糖基化，细胞核和细胞质中的蛋白质均可进行O-GlcNAc 糖基化修饰。 O-GlcNAc 修饰广泛参与细胞周期、基因转录、蛋白质翻译及加工、信号转导和细胞应激反应等多种细胞生命活 动。O-GlcNAc 修饰异常可导致糖尿病、心血管疾病、肿瘤和阿尔茨海默病等多种疾病的发生。肿瘤组织中蛋白 质O-GlcNAc 糖基化异常与肿瘤细胞的增殖和转移等密切相关。本文对各种肿瘤组织中蛋白质O-GlcNAc 糖基化 异常的特点以及癌基因或抑癌基因O-GlcNAc 糖基化在肿瘤细胞中的作用进行简要综述。 [关键词]　肿瘤；糖基化；蛋白质类；N- 乙酰葡萄糖胺 [中图分类号]　R73-05 [文献标志码] A [文章编号]　1000-7431 (2013) 11-1027-06 Protein O-GlcNAcylation and cancer ZHANG Xiao-bing, SHI Yi-kang National Glycoengineering Research Center, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, Shandong Province, China [A BSTRACT]　O-GlcNAcylation is the addition of a single N-acetylglucosamine (GlcNAc) moiety to the hydroxyl groups of serine or threonine residues of nuclear and cytoplasmic proteins. O-GlcNAc plays an important role in the regulation of many biological processes including, but not limited to, cell cycle progression, transcription, translation, signal transduction, stress response, etc. O-GlcNAc plays significant roles in the progression and etiology of various diseases including diabetes, cardiovascular disease, cancer and Alzheimer’s disease. The aberrant O-GlcNAcylation in tumor tissues is closely associated with cell proliferation and metastasis. This review is mainly involved the characteristics of protein O-GlcNAcylation alterations in different types of human cancer and the functions of O-GlcNAcylation in oncogenes and tumor suppressor genes. [KEY WORDS]　Neoplas