姜黄素对大鼠非酒精性脂肪肝的干预作用.pdfVIP

19 4 239 Vol. 19 No. 4 P. 239 2011 8 Chin J Integr Trad West Med Dig A g. 2011 : 1671-038X(2011) 04-0239-04 麦静 , 刘玉莉, 成 扬, 陈高峰, 平 键, 汪美凤 ( , 201203) : [ ] [] 30 Wistar , , 50mg/ kg , 12 , , - - O [ ] , -, ; ; , [ ] , : ; ; ; : R 5755 : A Intervention effect of curcumin on non-alcoholic fatty liver disease in rats M A I J ing-y i n, L I U Yu- li , CH E N G Yang , CH EN Gao-f eng , P I N G J ian, WA N G M ei-f e ng ( Sh g ang Hospital Affiliated to Shanghai U niversity of Traditional Chinese Medicine, Shanghai 201203, China) Abstract: [ Objective] T o st dy the effect of c rc min on non-alcoholic fatty liver disease ( NAFLD) in rats[ Methods] T hirty Wistar rats were randomly allocated to the control gro p, NAFLD model gro p and c rc min gro p Rats in the control gro p w ere fed w ith normal food- st ffs and those in the model and c rc min gro ps w ith high-fat foodst ffs C r min w as admin- istered at the dose of 50 mg kg- 1 d - 1 by gastric perf sionT he experiment period w as 12 w eeksAt the end of experiment, rats w ere sacrificed to collect the blood and liver tiss esSer m alanine aminotransferase( A LT ) , aspartate aminotransferase( AST ) activities and total cholesterol (T C) , hepatic gamma- gl tamyltransferase( - GT ) activity, triglycerides( TG) level, s peroxide dis- m tase( SOD) and gl tathione( GSH) activities w ere determined respectively Hemotoxin and Eo- sin staining and oil red O staining w ere performed to observe pathological changes in the liver tis- s es[ Results] C rc min red ced activities of ser m ALT, AST and h