改性果胶抗肿瘤机制研究进展.pdfVIP

※专题论述 食品科学 2015, Vol.36, No.15 293 改性果胶抗肿瘤机制研究进展 1 1 2 1,* 张文博 ，刘振华，袁雪艳，高启禹 （1.新乡医学院生命科学技术学院，河南 新乡 453003 ；2.新乡医学院公共卫生学院，河南 新乡 453003 ） 摘  要：果胶是一种以聚半乳糖醛酸为骨架、富含中性糖分支结构的植物杂多糖。通过理化手段对果胶进行改性， 可降低其分子质量和酯化度、修饰其微观结构、提高其生物利用度，经改性后的果胶能抑制肿瘤生长、诱导细胞凋 亡、增强肿瘤细胞对化疗药物的敏感性、抑制肿瘤血管新生和转移并增强机体的免疫响应。本文重点综述改性果胶 的抗肿瘤机制、吸收机制和抗肿瘤构效关系，并对其开发为功能食品的前景进行展望。 关键词：半乳糖凝集素-3 ；改性果胶；改性柑橘果胶；果胶；抗肿瘤活性 Progress in Antitumor Mechanisms of Modified Pectin 1 1 2 1,* ZHANG Wenbo , LIU Zhenhua , YUAN Xueyan , GAO Qiyu (1. School of Life Sciences and Technology, Xinxiang Medical University, Xinxiang 453003, China; 2. School of Public Health, Xinxiang Medical University, Xinxiang 453003, China) Abstract: Pectin is a complex class of plant polysaccharides, composed of a galacturonan backbone and neutral sugar side chains. Antitumor modified pectin fragments (MPs) can be prepared by physical and/or chemical modification of pectin to decrease its molecular mass, reduce its degree of esterification, modify its fine structure and improve its bioavailability. MPs can reportedly inhibit tumor growth, induce apoptosis, sensitize tumor cells to chemotherapeutic drugs, interfere with angiogenesis, suppress metastasis and modulate immunological responses. This review summarizes the antitumor mechanisms, bioabsorption mechanisms and structure-activity relationship of MPs. We also analyze the prospects for developing MPs-based functional foods. Key words: galectin-3 (Gal-3); modified pectins (MPs); modified citrus pectin (MCP); pectin; antitumor activity 中图分类号：TS201.2