微生物共培养在新活性化合物挖掘中的研究进展.PDFVIP

微生物学通报 Oct. 20, 2017, 44(10): 2437−2442 Microbiology China /wswxtbcn tongbao@ DOI: 10.13344/j.microbiol.china.160885 专论与综述 微生物共培养在新活性化合物挖掘中的研究进展 * 赵曦 解云英 白利平 (中国医学科学院北京协和医学院医药生物技术研究所 北京 100050) 摘 要：微生物次级代谢产物结构新颖、活性多样，一直以来都是药物及其先导化合物的重要 来源。但近年来在普通微生物纯培养中发现的新活性物质不断减少，重复发现逐渐增加；而微 生物共培养因更加接近微生物生长的自然环境，在药物及其先导物挖掘方面发挥着越来越重要 的作用。本文分析了近5 年来利用真菌vs 真菌、真菌vs 细菌共培养挖掘新活性化合物的研究 现状，以及研究中存在的问题。 关键词：共培养，真菌，次级代谢产物 Progress of microbial co-culture in new compound mining * ZHAO Xi XIE Yun-Ying BAI Li-Ping (Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences Peking Union Medical College, Beijing 100050, China) Abstract: Microbial secondary metabolites have been an important source of drugs and their leading compounds because of their novel chemical structures and various biological activities. However, in recent years, there is a high frequency of re-discovery and a low frequency of new discovery of active compounds from microbial pure culture. As microbial co-culture is closer to the natural environment of microbial growth, it plays an important role in new compound mining. Here, we review the progress of new compound mining through co-culture from fungi vs fungi and fungi vs bacteria, and the current problems of this field for future research is also mentioned. Keywords: Co-culture, Fungi,