严重脓毒症抗生素应用策略.pptVIP

Severe Sepsis抗生素应用策略 中山大学附属第一医院SICU 陈娟 内容提要 SEPSIS概念 合理使用抗生素的概念 Severe Sepsis抗生素治疗原则 根据PK/PD用药 根据本院/本科室流行病学监测资料用药 知己知彼——掌握病情，熟悉药物 联合用药 Sepsis相关概念 Systemic Inflammatory Response Syndrome (SIRS)Two or more of the following: Temperature of 38oC or 360C Heart rate of 90 Respiratory rate of 20 WBC count 12 x 109/L or 4 x 109/L or 10% immature forms (bands) Sepsis相关概念 SepsisSIRS plus a culture-documented infection Severe SepsisSepsis plus organ dysfunction, hypotension, or hypoperfusionSeptic Shock Sepsis plus Hypotension (despite fluid resuscitation) or hypoperfusion 严重脓毒症 Sepsis+ 低血压：除外其他原因，