滨蒿总黄酮抗炎、镇咳、解热作用的实验研究20150320稿件1.docVIP

滨蒿总黄酮抗炎、镇咳、解热作用的实验研究 史银基1，司丽君2,刘 燕2，杨巧丽2，姚 华2，史玉柱2，王 雪2，顾政一2，黄 华2 （1.新疆医科大学，新疆，乌鲁木齐 830011； 2.新疆维吾尔自治区药物研究所，新疆，乌鲁木齐 830004） 摘要：目的 对滨蒿总黄酮进行抗炎、镇咳、解热作用的研究。方法 通过二甲苯致小鼠耳廓肿胀模型和冰醋酸致小鼠腹腔毛细血管炎性渗出模型，观察滨蒿总黄酮的抗炎作用；采用氨水引咳法和枸橼酸引咳法，观察其镇咳作用；通过干酵母诱导的大鼠发热模型，考察其解热作用。结果 滨蒿总黄酮对小鼠耳廓炎性肿胀有明显的抑制作用，其0.2g/kg、0.4g/kg剂量的肿胀抑制率均为29.4%；对冰醋酸致小鼠中图分类号R965.1 文献标识码： Effects of Total Flavonoids from Artemisia?Scoparia on Anti-inflammatory, Relieving Cough and Antipyretic SHI Yin-ji1，SI Li-jun2，GU Zheng-yi2， LIU Yan2，YANG QiaoO-li2，YAO Hua2，WANG Xue2，SHI Yu-zhu2，HUANG Hua2 （1 Xinjiang Medical University, Urumqi 830011.2.Xinjiang Institute of Materia Medic, Urumqi 830004） ABSTRACT: OBJECTIVE Observe the effects of total flavonoids from Artemisia?Scoparia on anti-inflammatory, relieving cough and antipyretic. METHODS Through the tests of ear conch induced by xylene and glacial acetic acid-induced mouse peritoneal capillary inflammatory exudate model, to observe the anti-inflammatory effects of total flavonoids from Artemisia?Scoparia. Relieving cough caused by the irritation of ammonia water in mice and cough model induced by citric acid in guinea pigs were used to observe the antitussive action. The models of dry yeast-induced fevered rats was used to study the antipyretic effects. RESULTS Total flavonoids from Artemisia?Scoparia could inhibit the degree of ear conch induced by xylene, dose of 0.2g/kg,0.4g/kg could inhibit the mice auricle inflammatory swelling inhibition rate was 29.37%; Inhibit the degree of glacial acetic acid-induced mouse peritoneal capillary inflammatory exudate model also, dose of 0.4g/kg inflammatory swelling inhibition rate was 29.9%; The mice cough response inhibition rate was 22.2% and 35.6%，wich dose of 0.2g/kg and 0.4g/kg of total flavonoids from Artemisia ScopariaDose of 0.1 g/kg，0.2 g/kg，0.4g/kg of total flavonoids from Artemisia?Scoparia to guinea pig cough caused by citric acid inhibition rates were 32.1%, 41.3% and 49.0% respecti