MR医学影像文献Li-2016-Au@MnS@ZnS Core_Shell_Shell Nanopartic.pdfVIP

Research Article Au@MnS@ZnS Core/Shell/Shell Nanoparticles for Magnetic Resonance Imaging and Enhanced Cancer Radiation Therapy Meifang Li,† Qi Zhao,† Xuan Yi,† Xiaoyan Zhong,† Guosheng Song,‡ Zhifang Chai,† Zhuang Liu,*,‡ and Kai Yang*,† †School of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Medical College of Soochow University, Suzhou, Jiangsu 215123, China ‡ Jiangsu Key Laboratory for Carbon-Based Functional Materials Devices, Institute of Functional Nano Soft Materials Laboratory (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, China S *Supporting Information ABSTRACT: Although conventional radiotherapy (RT) has been widely used in the clinic to treat cancer, it often has limited therapeutic outcomes and severe toxic effects. There is still a need to develop theranostic agents with both imaging and RT- enhancing functions to improve the accuracy and efficiency of RT. Herein we synthesize Au@MnS@ZnS core/shell/shell nanoparticles with polyethylene glycol (PEG) functionalization, yielding Au@MnS@ZnS-PEG nanoparticles with great stability in different physiological solutions and no significant cytotoxicity. It is found that Au@MnS@ZnS-PEG nanoparticles can enhance the cancer cell killing efficiency induced by RT, as evidenced by multiple in vitro assays. Owing to the existence of paramagnetic Mn2+ in the nanoparticle shell, our Au@MnS@ZnS-PEG can be used as a contrast agent for T1-weighted magnetic resonance (MR) imaging, which reveals the efficient accumulati