MR医学影像文献Ni-2016-PEGylated NaHoF4 nanoparticles as cont.pdfVIP

Biomaterials 76 (2016) 218e225 Contents lists available at ScienceDirect Biomaterials journal homepage: /locate/biomaterials PEGylated NaHoF4 nanoparticles as contrast agents for both X-ray computed tomography and ultra-high field magnetic resonance imaging Dalong Ni a, Jiawen Zhang b, Wenbo Bu a, **, Chen Zhang a, Zhenwei Yao b, ***, Huaiyong Xing a, Jing Wang b, Fei Duan b, Yanyan Liu a, Wenpei Fan a, Xiaoyuan Feng b, Jianlin Shi a, * a State Key Laboratory of High Performance Ceramics and Superfi ne Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China b Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040, China a r t i c l e i n f o a b s t r a c t Article history: It is well-known that multimodal imaging can integrate the advantages of different imaging modalities Received 15 July 2015 by overcoming their individual limitations. As ultra-high field magnetic resonance imaging (MRI) will be Received in revised form inevitably used in future MRI/X-ray computed tomography (CT) scanner, it is highly expected to develop 16 October 2015 high-performance nano-contrast agents for ultra-high field MR and CT dual-modality imaging, which has Accepted 26 October 2015 Available online 28 October 2015 not been reported yet. Moreover, specific behavior of nano-contrast agents for ultra-high field MRI is a challenging work and still remains unknown. Herein, a novel type of NaHoF4 nanoparticles (NPs) with