MR医学影像文献Zhu-2016-Evaluating early response of cervical.pdfVIP

Zhu et al. BMC Cancer (2016) 16:79 DOI 10.1186/s12885-016-2116-5 RESEARCH ARTICLE Open Access Evaluating early response of cervical cancer under concurrent chemo-radiotherapy by intravoxel incoherent motion MR imaging 1† 2† 1 1 2 2 3 1* Li Zhu , Lijing Zhu , Hua Shi , Huanhuan Wang , Jing Yan , Baorui Liu , Weibo Chen , Jian He , Zhengyang Zhou1*, Xiaofeng Yang4 and Tian Liu4 Abstract Background: Intravoxel incoherent motion (IVIM) MR imaging has been applied in researches of various diseases, however its potential in cervical cancer patients has not been fully explored. The purpose of this study was to investigate the feasibility of IVIM MR imaging to monitor early treatment response in patients receiving concurrent chemo-radiotherapy (CCRT) for advanced cervical cancers. Methods: Twenty-one patients receiving CCRT for advanced cervical cancer were prospectively enrolled. MR examinations including IVIM imaging (with 14 b values, 0 ~ 1000 s/mm2) were performed at 4 time points: 1-week prior to, 2-week and 4-week during, as well as immediately post CCRT (within 1 week). The apparent diffusion coefficient (ADC) maps were derived from the mono-exponential model, while the diffusion coefficient (D), perfusion fraction (f) and pseudo-diffusion coefficient (D*) maps were calculated from the bi-exponential model. Dynamic changes of ADC, D, f and D* in cervical cancers were investigated as early surrogate markers for treatment response. Results: ADC and D values increased throughout the CCRT course. Both f and D* increased in the first 2 to 3 weeks of CCRT and started to decrease around 4 weeks of CCRT. Significant increase of f value was observed from prior to CCRT (f1 = 0.12 ± 0.52)