利用基因敲除小鼠研究发热机制的进展-中国病理生理杂志.pdfVIP

Chi ese Jour al of Pathophysiology 2002, 18( 9) : 1151- 1156 ! 1151 ! [ ] 1000- 4718(2002) 09- 1151- 06 ! ! * 李沧海, 霍海如, 姜廷良 ( , 100700) Progress in studying the mechanism of fever using knockout mice LI Ca g- hai,HUO Hai- ru, JIANG Ti g- lia g ( Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beij ing 100700, China) ∀A Review# I creasi g evide ce suggests that a complex et- work of fever i ductio pathways i mammalia exists. I this article, the overview of rece t studies o the mecha ism of fever i duced by differe t pyroge s usi g IL- 1, IL- 1R, ICE, IL- 1ra, IL- 1RacP, IL- 6, IL- 10,TNFR, cPLA , COX, EP, AT , 2 2 iNOS a d D2/ 3 k ockout mice is prese ted. Hyperthermia respo d to localized i fectio / i flammatio ( e. g. , sc i jectio of turpe ti e) is mediated by IL- 1a d IL- 6 i tur . While fever i duced by systemic i fectio / i flammatio ( e.g. , treatme t with LPS i traperito eally) varies with the differe t doses of pyroge s admi is tered . Fever caused by a low dose of LPS admi istered ip is IL- 6 depe de t , but the IL- 6 i depe de t pathway is crucial for the fever evoked by a high dose of LPS. Febrile respo ses duri g both local a d systemic i fectio / i flammatio develop totally through ce tral PGE depe de t mecha ism, but some stress i duced 2 hyperthermia otherwise. [ ] , ; ; ; [ KEY WORDS] Mice, k ockout; Fever; Cytoki es; Prostagla di s [ ] R3646 [ ] A 50 , , ∃ ∃∃ ,