局部晚期非小细胞肺癌治疗的争议与共识-胸外科.pdfVIP

肿瘤防治杂志 2004 年 7 月第 11 卷第 7 期　　CHIN J CANCER PREV TREAT ,July 2004 ,Vol. 11 　No. 7 7·49 · 综述·讲座 局部晚期非小细胞肺癌治疗的争议与共识 周清华 四川大学华西医院 四川省肺癌分子重点实验室、肿瘤中心 , 四川 成都 610041 Treatment of locally advanced nonsmall cell lung cancer : Agreement and disagreement ZHOU Qinghua Key Laboratory of Lung Cancer Molecular Biology of Sichuan Province , Cancer Center, West China Hospital , Sichuan University , Chengdu 610041 , P. R . China 【摘要】　肺癌是发病率和死亡率增长最快, 对人类健康和生命威胁最大的恶性肿瘤。完全性切除是目前治疗肺癌 的最好方法。但是, 仅有约 1/ 3 的肺癌适合于外科治疗, 另 2/ 3 的肺癌由于伴有远处转移或侵犯邻近器官而被视为 不可手术。近年来, 随着心血管外科理论和技术在肺癌外科中的应用, 使得肺切除合并受侵的左心房、胸主动脉、 上腔静脉和肺动脉的整块切除成为可能。这些过去被视为外科禁忌证和无治愈希望的局部晚期肺癌, 不但获得肿 瘤完全切除、无肿瘤复发转移, 而且获得长期生存和良好的生活质量。 ( ) 肿瘤防治杂志, 2004 , 11 7 :749 - 752 [ ABSTRACT] 　Lung cancer has become the most frequent malignant tumor in the world which its mortality and morbidity is in creasing fastest among all the cancers , and it also has become the No. 1 malignant tumors which is harmful to human health and life , and the first killer in all cancers. . Complete surgical resection is currently the best treatment modality for lung cancer. However , only one third of patients with lung cancer can be identified as operative candidates , For the other two thirds is inoperable , because they have late disease with distant metastasis or locally advanced lung cancer involving neighboring organs. Recently , introduction of the theory and technique of cardiovascular surgery into lung cancer surgery has made possible en bloc resection of the lung combin