槲皮素干预试验性慢性肾衰大鼠尿量与尿蛋白量-中国现代应用药学.pdfVIP

槲皮素干预实验性慢性肾衰大鼠尿量与尿蛋白量动态变化 王天然，邹自英，李继红，李素华，陈莉，胡晓莉(成都军区总医院检验科，成都 610083) 摘要：目的 观察槲皮素对实验性慢性肾衰大鼠尿量和尿蛋白量的影响。方法 给实验大鼠饲以含腺嘌呤饲料 2 月造成 慢性肾衰；干预组经口给予槲皮素(100 mg·kg1·d1×42 d)治疗；每周测定实验大鼠 24 h 尿量和尿蛋白含量。结果 与肾 衰对照组比较，槲皮素干预组大鼠肾脏指数、肾组织含水量、血清肌酐和尿素氮均显著降低；在整个观察过程中，干预 组平均 24 h 尿量均显著增多，24 h 尿蛋白量均显著减少。结论 槲皮素对大鼠实验性慢性肾衰具有显著防治作用。 关键词：槲皮素；慢性肾衰；尿量；尿蛋白量 中图分类号：R285.5 文献标志码：A 文章编号：1007-7693(2012)01-0008-04 作者简介：王天然，男，硕士，副主任技师 Tel: (028E-mail: WTR1957@126.com ·8 · Chin JMAP, 2012 January, Vol.29 No.1 中国现代应用药学2012 年 1 月第 29 卷第 1 期 Effects of Quercetin on Quantitative Changes of Urine Volume and Uric Protein in Rats with Experimental Chronic Renal Failure WANG Tianran, ZHOU Ziying, LI Jihong, LI Suhua, CHENG Li, HU Xiaoli(Department of Clinical Tests, General Hospital of Chengdu Military Area, Chengdu 610083, China) ABSTRACT: OBJECTIVE The effects of quercetin on quantitative changes of urine and uric protein in rats with experimental chronic renal failure were studied. METHODS The rats in control and treated groups were fed with 0.75%  1 adenine for 2 months to build up chronic renal failure modle; and the quercetin were administered orally (100 mg·kg ·d ) for 42 days to the rats in treated group. The quantities of 24 h urine and uric protein were determined weekly. RESULTS The renal indexes, water percentages of renal tissue, serum CREA and BUN levels in treated group decreased significantly when compared with those in control group (P ＜0.001). The 24 h urine volume in treated group increased (P ＜0.001), and 24 h uric protein decreased (P ＜0.001) significantly than those in the control group. CONCLUSION Qercetin is effective in preventing and curing of chronic r