前列腺癌发生发展相关信号转导通路的研究进展-肿瘤药学.pdfVIP

- 96 - 肿瘤药学 2016 年 4 月第 6 卷第 2 期　Anti-tumor Pharmacy, April 2016, Vol. 6, No. 2 ●综　　述● 前列腺癌发生发展相关信号转导通路的研究进展 * 申利 贤 ，周　斌 ，李海艳 ，闵　可，蒋敏媚 ，郭　玉 （南华大学药物药理研究所，湖南省分子靶标新药研究协 同创新 中心，湖南 衡 阳，42 100 1 ） 摘要：前列腺癌的发生与发展经历一系列复杂的过程，细胞内信号通路的异常是前列腺癌发生发展的重要 机制之一。研究表明 Hedgehog 信号通路、Wnt 信号通路、Notch 信号通路和 MAPK 信号通路与前列腺癌的发 生、浸润、转移等有密切关系。本文就现阶段与前列腺癌发生发展相关的信号转导通路的研究进展作一简要综 述，以期为临床早期诊断和防治前列腺癌提供新的靶点和参考。 关键词：前列腺癌；Hedgehog 信号通路；Wnt 信号通路；Notch 信号通路；MAPK 信号通路 中图分类号：R965.1，R737.6　文献标识码 ：A　文章编号：2095-1264（2016）02-0096-07 doi：10.3969/j.issn.2095-1264.2016.02.03 Advances in the Signal Transduction Pathway Related to the Development of Prostate Cancer * SHEN Lixian, ZHOU Bin, LI Haiyan, MIN Ke, JIANG Minmei, GUO Yu (Institute of Pharmacy and Pharmacology, University of South China; Hunan Province Coop erative innovation Center f or Molecular Target New Drug Study, Hengyang, Hunan, 421001, China) Abstract: The development and progression of prostate cancer is a complex process. Abnormalities in the intracellular signaling pathway are important mechanisms in the development and progression of prostate cancer. Previous studies have demonstrated that the Hedgehog signaling pathway, WNT signaling pathway, Notch signaling pathway and MAPK signaling pathway played important roles in prostate cancer development, progression and metastasis. In this paper, we made a brief summary on the relevant signal transduction pathway in the occurrence and development of prostate ca