核受体fxr代谢调控作用及肿瘤细胞增殖机制研究进展-生理学报.pdfVIP

252 生理学报Acta Physiologica Sinica , April 25, 2014, 66(2): 252–258 DOI: 10.13294/j.aps.2014.0030 综 述 核受体FXR代谢调控作用及肿瘤细胞增殖机制研究进展 谢杨，周雪妍，郝海平，王广基* 中国药科大学天然药物活性组分与药效国家重点实验室，药物代谢动力学重点实验室，南京 210009 X (farnesoid X receptor, FXR) FXR 摘 要：类法尼酯衍生物 受体 是配体激活的转录因子，为核受体超家族的主要成员。 在胆汁 FXR 酸代谢、胆固醇代谢、脂代谢以及糖代谢中发挥重要作用。近期研究显示， 在代谢性疾病，如高糖血症和高脂血症， 以及肠道炎症性疾病、肝再生，甚至肿瘤细胞的增殖和凋亡中发挥重要的调控作用。然而现阶段对于FXR 的代谢调控作用 FXR FXR 在肿瘤发生、发展中的意义尚不明了，甚至存在争议。本文综述了 对代谢的调控作用，以及 对肿瘤细胞增殖的不 同作用和相关机制研究的新进展。 X 关键词：类法尼酯衍生物 受体；代谢调控；肿瘤；增殖 中图分类号：R329 Progress in the role of farnesoid X receptor in metabolic regulation and tumor cell proliferation XIE Yang, ZHOU Xue-Yan, HAO Hai-Ping, WANG Guang-Ji* State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China Abstract: Farnesoid X receptor (FXR) is a ligand-activated transcriptional factor belonged to the superfamily of nuclear receptors. In the past decades, FXR has been found with important roles in the regulation of metabolic homeostasis of bile acids, cholesterol, lipids and carbohydrates. Recent studies further demonstrate the potential protective effect of FXR against metabolic diseases, such as hyperglycemia and hyperlipidemia, as well as inflammatory bowel diseases (IBD). In addition, FXR plays an essential role in liver regeneration, tumor cell proliferation and apoptosis. However, the role of FXR in the development of tumor is still obscure and even with discrepancy. This article reviews the function of FXR in metabolic regulation and rec